Dynamic changes in liver function parameters in patients with coronavirus disease 2019: a multicentre, retrospective study

Abstract Background Liver injuries have been reported in patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the clinical role played by severe acute respiratory syndrome 2 (SARS-CoV-2). Methods In this multicentre, retrospective study, parameters of liver function tests COVID-19 inpatients were compared between various time-points reference SARS-CoV-2 shedding, and 3 7 days before first detection viral shedding was regarded as baseline. Results total, 70 enrolled. Twenty-two (31.4%) had a self-medication history after illness. At baseline, 10 (14.3%), (10%), 9 (12.9%), (2.9%), 15 (21.4%), 4 (5.7%) already abnormal alanine aminotransferase (ALT), aspartate (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), albumin, total bilirubin (TBIL) values, respectively. ALT AST rates levels did not show any significant dynamic changes during full period (all p > 0.05). The GGT rate ( = 0.008) level 0.033) significantly increased on day shedding. Meanwhile, no simultaneous increases ALP observed. TBIL 1 5 < Albumin decrease increased, decreased consistently from baseline clearance Thirteen (18.6%) chronic disease, two whom died. increase Conclusions does directly lead elevations but may result TBIL; albumin extraordinarily even when ended.